User blog comment:TAGDavid/Demon Construct/@comment-26523472-20150819003937/@comment-26069426-20150819132503

David,

Remember, every time you attack a unit on the left or right, you're minusing. Unless you can gain advantage from destroying monsters (Hero Drum), or you know for sure you'll be disrupting their advantage engine, you should attack center.

There are exceptions, of course, but this is a fast and loose rule you should abide. For example, if your opponent has few to no cards in hand, and you can't beat them by going direct, kill the monsters. They'll have a hard time replacing them. Although, in the end, this is disrupting their advantage engine.